Empirical Inference Poster 2010

Augmentation of fMRI Data Analysis using Resting State Activity and Semi-supervised Canonical Correlation Analysis

Resting state activity is brain activation that arises in the absence of any task, and is usually measured in awake subjects during prolonged fMRI scanning sessions where the only instruction given is to close the eyes and do nothing. It has been recognized in recent years that resting state activity is implicated in a wide variety of brain function. While certain networks of brain areas have different levels of activation at rest and during a task, there is nevertheless significant similarity between activations in the two cases. This suggests that recordings of resting state activity can be used as a source of unlabeled data to augment kernel canonical correlation analysis (KCCA) in a semisupervised setting. We evaluate this setting empirically yielding three main results: (i) KCCA tends to be improved by the use of Laplacian regularization even when no additional unlabeled data are available, (ii) resting state data seem to have a similar marginal distribution to that recorded during the execution of a visual processing task implying largely similar types of activation, and (iii) this source of information can be broadly exploited to improve the robustness of empirical inference in fMRI studies, an inherently data poor domain.

Author(s): Shelton, JA. and Blaschko, MB. and Bartels, A.
Year: 2010
Month: December
Day: 0
Bibtex Type: Poster (poster)
Digital: 0
Electronic Archiving: grant_archive
Event Name: NIPS 2010 Women in Machine Learning Workshop (WiML 2010)
Event Place: Whistler, BC, Canada
Language: en
Organization: Max-Planck-Gesellschaft
School: Biologische Kybernetik
Links:

BibTex

@poster{7044,
  title = {Augmentation of fMRI Data Analysis using Resting State Activity and Semi-supervised Canonical Correlation Analysis},
  abstract = {Resting state activity is brain activation that arises in the absence of any task, and is usually measured
  in awake subjects during prolonged fMRI scanning sessions where the only instruction given is to
  close the eyes and do nothing. It has been recognized in recent years that resting state activity is
  implicated in a wide variety of brain function. While certain networks of brain areas have different
  levels of activation at rest and during a task, there is nevertheless significant similarity between
  activations in the two cases. This suggests that recordings of resting state activity can be used as
  a source of unlabeled data to augment kernel canonical correlation analysis (KCCA) in a semisupervised
  setting. We evaluate this setting empirically yielding three main results: (i) KCCA tends
  to be improved by the use of Laplacian regularization even when no additional unlabeled data are
  available, (ii) resting state data seem to have a similar marginal distribution to that recorded during
  the execution of a visual processing task implying largely similar types of activation, and (iii) this
  source of information can be broadly exploited to improve the robustness of empirical inference in
  fMRI studies, an inherently data poor domain.},
  organization = {Max-Planck-Gesellschaft},
  school = {Biologische Kybernetik},
  month = dec,
  year = {2010},
  slug = {7044},
  author = {Shelton, JA. and Blaschko, MB. and Bartels, A.},
  month_numeric = {12}
}