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Miscellaneous 2018

Relaxation-compensated multi-pool CEST signal at 7T MRI of WHO IV gliomas is dependent on the anatomic localization

{As patients with WHO IV\mbox{$^\circ$} gliomas are still having a dismal prognosis, further tumor characterization is needed. With prognosis and histopathological parameters being dependent on tumor localization, and Chemical-Exchange-Saturation-Transfer(CEST) MRI at 7T being one of the latest advances in tumor imaging, we have prospectively evaluated CEST signals in 21 patients. Amide CEST and ADC parameters are significantly different with regard to brain hemispheres and correlating. CEST NOE(Nuclear Overhauser-Effect) is not different with regard to brain hemispheres, but in case of contact to the subventricular zone, which is accompanied by worse prognosis. NOE is possibly showing complementary information to Amide CEST.}

Author(s): Dreher, C and Oberhollenzer, J and Windschuh, J and Meissner, J-E and Sahm, F and Bendszus, M and Unterberg, A and Wick, W and Bachert, P and Ladd, ME and Schlemmer, H-P and Zaiss, M and Radbruch, A and Paech, D
Book Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Year: 2018
Bibtex Type: Miscellaneous (misc)
Electronic Archiving: grant_archive

BibTex 

@misc{DreherOWMSBUWBLSZRP2018,
  title = {{Relaxation-compensated multi-pool CEST signal at 7T MRI of WHO IV gliomas is dependent on the anatomic localization}},
  booktitle = {{Joint Annual Meeting ISMRM-ESMRMB 2018}},
  abstract = {{As patients with WHO IV\mbox{$^\circ$} gliomas are still having a dismal prognosis, further tumor characterization is needed. With prognosis and histopathological parameters being dependent on tumor localization, and Chemical-Exchange-Saturation-Transfer(CEST) MRI at 7T being one of the latest advances in tumor imaging, we have prospectively evaluated CEST signals in 21 patients. Amide CEST and ADC parameters are significantly different with regard to brain hemispheres and correlating. CEST NOE(Nuclear Overhauser-Effect) is not different with regard to brain hemispheres, but in case of contact to the subventricular zone, which is accompanied by worse prognosis. NOE is possibly showing complementary information to Amide CEST.}},
  year = {2018},
  slug = {dreherowmsbuwblszrp2018},
  author = {Dreher, C and Oberhollenzer, J and Windschuh, J and Meissner, J-E and Sahm, F and Bendszus, M and Unterberg, A and Wick, W and Bachert, P and Ladd, ME and Schlemmer, H-P and Zaiss, M and Radbruch, A and Paech, D}
}