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Comparison of two alternative sequences for human in-vivo brain MR Current Density Imaging (MRCDI)
{MRCDI is a novel technique, utilizing different phase-sensitive MR methods for non-invasive measurements of weak currents in the human body, which is important in several neuroscience applications. Here, we compare the in-vivo performance of two different MR methods, multi-echo spin echo (MESE) and steady-state free precession free induction decay (SSFP-FID), with single- vs. multi-gradient-echo readouts. We demonstrate that multi-gradient-echo readouts improve both methods. We validate the linear dependence of the measured current-induced magnetic field on the injected current strength for both methods, and propose the more efficient SSFP-FID method as being well suited for highly sensitive single-slice human in-vivo MRCDI.}
@misc{item_2602953, title = {{Comparison of two alternative sequences for human in-vivo brain MR Current Density Imaging (MRCDI)}}, booktitle = {{Joint Annual Meeting ISMRM-ESMRMB 2018}}, abstract = {{MRCDI is a novel technique, utilizing different phase-sensitive MR methods for non-invasive measurements of weak currents in the human body, which is important in several neuroscience applications. Here, we compare the in-vivo performance of two different MR methods, multi-echo spin echo (MESE) and steady-state free precession free induction decay (SSFP-FID), with single- vs. multi-gradient-echo readouts. We demonstrate that multi-gradient-echo readouts improve both methods. We validate the linear dependence of the measured current-induced magnetic field on the injected current strength for both methods, and propose the more efficient SSFP-FID method as being well suited for highly sensitive single-slice human in-vivo MRCDI.}}, year = {2018}, slug = {item_2602953}, author = {G\"oksu, C and Hanson, LG and Siebner, HR and Ehses, P and Scheffler, K and Thielscher, A} }