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Miscellaneous 2018

Challenges in estimating T1 Relaxation Times of Macromolecules in the Human Brain at 9.4T

{In order to determine the T1 relaxation times of the metabolites in human brain including the ones that have either shorter T2 relaxation times or represent J-coupled spin systems, shorter TE times have to be chosen where there is a significant macromolecular contribution. Therefore, the behaviour of macromolecules (MMs) and their relaxation have to be understood clearly. In [1] the T1 relaxation time of the macromolecular baseline has been determined as a whole using single inversion recovery but values have not been provided for individual MMs, in [2] it has been estimated for the MM peak at 0.93 ppm. Here we attempt to understand the T1 relaxation pattern for the individual macromolecules at 9.4T in the human brain with a double inversion recovery (DIR) technique in order to measure the relaxation of individual MM components which relax at different rates and uniquely impact the overlying metabolite spectrum in traditional excitation approaches.}

Author(s): Murali-Manohar, S and Wright, AM and Henning, A
Book Title: MRS Workshop 2018 Metabolic Imaging
Year: 2018
Bibtex Type: Miscellaneous (misc)
Electronic Archiving: grant_archive

BibTex 

@misc{item_3006105,
  title = {{Challenges in estimating T1 Relaxation Times of Macromolecules in the Human Brain at 9.4T}},
  booktitle = {{MRS Workshop 2018 Metabolic Imaging}},
  abstract = {{In order to determine the T1 relaxation times of the metabolites in human brain including the ones that have either shorter T2 relaxation times or represent J-coupled spin systems, shorter TE times have to be chosen where there is a significant macromolecular contribution. Therefore, the behaviour of macromolecules (MMs) and their relaxation have to be understood clearly. In [1] the T1 relaxation time of the macromolecular baseline has been determined as a whole using single inversion recovery but values have not been provided for individual MMs, in [2] it has been estimated for the MM peak at 0.93 ppm. Here we attempt to understand the T1 relaxation pattern for the individual macromolecules at 9.4T in the human brain with a double inversion recovery (DIR) technique in order to measure the relaxation of individual MM components which relax at different rates and uniquely impact the overlying metabolite spectrum in traditional excitation approaches.}},
  year = {2018},
  slug = {item_3006105},
  author = {Murali-Manohar, S and Wright, AM and Henning, A}
}