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Miscellaneous 2019

Model-free generation of CEST contrast using principal components of Z-spectra at 3 T

{Fitting of spectrally selective CEST contrasts requires models with limiting assumptions. Snapshot CEST allows us to densely sample the Z-spectrum with rapid volumetric imaging within a clinically feasible scan time. With over 60k spectra available per subject, statistically-driven analysis methods are now possible. Here we demonstrate that principle component analysis can be used for model-free analysis of spectral features. Projection of Z-spectra onto principle components from a group of healthy subjects provides several relevant contrasts which reveal anatomical detail and correlate with Gadolinium uptake signatures in a brain tumor patient.}

Author(s): Deshmane, A and Zaiss, M and Schuppert, M and Herz, K and Scheffler, K
Book Title: ISMRM 27th Annual Meeting & Exhibition
Year: 2019
Bibtex Type: Miscellaneous (misc)
Electronic Archiving: grant_archive

BibTex 

@misc{item_3054590,
  title = {{Model-free generation of CEST contrast using principal components of Z-spectra at 3 T}},
  booktitle = {{ISMRM 27th Annual Meeting \& Exhibition}},
  abstract = {{Fitting of spectrally selective CEST contrasts requires models with limiting assumptions. Snapshot CEST allows us to densely sample the Z-spectrum with rapid volumetric imaging within a clinically feasible scan time. With over 60k spectra available per subject, statistically-driven analysis methods are now possible. Here we demonstrate that principle component analysis can be used for model-free analysis of spectral features. Projection of Z-spectra onto principle components from a group of healthy subjects provides several relevant contrasts which reveal anatomical detail and correlate with Gadolinium uptake signatures in a brain tumor patient.}},
  year = {2019},
  slug = {item_3054590},
  author = {Deshmane, A and Zaiss, M and Schuppert, M and Herz, K and Scheffler, K}
}