@article{item_3069230,
  title = {{Whole-brain snapshot CEST imaging at 7 T using 3D-EPI}},
  journal = {{Magnetic Resonance in Medicine}},
  abstract = {{Purpose The aim of this work is to develop a fast and robust CEST sequence in order to allow the acquisition of a whole-brain imaging volume after a single preparation block (snapshot acquisition). Methods A 3D-CEST sequence with an optimized 3D-EPI readout module was developed, which acquires the complete k-space data following a single CEST preparation for 1 saturation offset. Whole-brain mapping of the Z-spectrum with 2 mm isotropic resolution is achieved at 68 saturation frequencies in 5 minutes (4.33 s per offset). We analyzed the urn:x-wiley:07403194:media:mrm27866:mrm27866-math-0002 distribution in order to optimize urn:x-wiley:07403194:media:mrm27866:mrm27866-math-0003 correction and to provide accurate CEST quantification across the whole brain. Results We obtained maps for 3 different CEST contrasts from 4 healthy subjects. Based on our urn:x-wiley:07403194:media:mrm27866:mrm27866-math-0004 distribution analysis, we conclude that 3 urn:x-wiley:07403194:media:mrm27866:mrm27866-math-0005 sampling points allow for sufficient compensation of urn:x-wiley:07403194:media:mrm27866:mrm27866-math-0006 variations across most of the brain. Two brain regions, the cerebellum and the temporal lobes, are difficult to quantify at 7 T due to very low urn:x-wiley:07403194:media:mrm27866:mrm27866-math-0007 that was achieved in these regions. Conclusions The proposed sequence enables robust acquisition of 2 mm isotropic whole-brain CEST maps at 7 Tesla within a total scan time of 16 minutes.}},
  volume = {82},
  number = {5},
  pages = {1741--1752},
  publisher = {Wiley-Liss},
  address = {New York},
  year = {2019},
  slug = {item_3069230},
  author = {Akbey, S and Ehses, P and Stirnberg, R and Zaiss, M and St\"ocker, T}
}