@article{item_3166300,
  title = {{Early detection and monitoring of cerebral ischemia using calcium-responsive MRI probes}},
  journal = {{Proceedings of the National Academy of Sciences of the United States of America}},
  abstract = {{Cerebral ischemia is one of the leading causes of mortality and disability in infants and adults and its timely diagnosis is essential for an efficient treatment. We present a methodology for fast detection and real-time monitoring of fluctuations of calcium ions associated with focal ischemia using a molecular functional MRI approach. We used a dinuclear paramagnetic gadolinium(III) complex chelate that changes MR image contrast through its reversible interaction with extracellular calcium ions, while applying a remote transient middle cerebral artery occlusion as a model for ischemic stroke. Our method sensitively recognizes the onset and follows the dynamics of the ischemic core and penumbra with submillimeter spatial and second-scale temporal resolution, thus paving the way for noninvasive monitoring and development of targeted treatment strategies for cerebral ischemia.}},
  volume = {116},
  number = {41},
  pages = {20666--20671},
  publisher = {National Academy of Sciences},
  address = {Washington, D.C.},
  year = {2019},
  slug = {item_3166300},
  author = {Savi\'c, T and Gambino, G and Bokharaie, VS and Noori, HR and Logothetis, NK and Angelovski, G}
}