@article{item_3174176,
  title = {{Test\textendashRetest Reliability of the Brain Metabolites GABA and Glx With JPRESS, PRESS, and MEGA-PRESS MRS Sequences in vivo at 3T}},
  journal = {{Journal of Magnetic Resonance Imaging}},
  abstract = {{Background The optimization of magnetic resonance spectroscopy (MRS) sequences allows improved diagnosis and prognosis of neurological and psychological disorders. Thus, to assess the test\textendashretest and intersequence reliability of such MRS sequences in quantifying metabolite concentrations is of clinical relevance. Purpose To evaluate the test\textendashretest and intersequence reliability of three MRS sequences to estimate GABA and Glx \textequals Glutamine+Glutamate concentrations in the human brain. Study Type Prospective. Subjects Eighteen healthy participants were scanned twice (range: 1 day to 1 week between the two sessions) with identical protocols. Field Strength/Sequence 3T using a 32-channel SENSE head coil in the PCC region; PRESS, JPRESS, and MEGA-PRESS sequences. Assessment Metabolite concentrations were estimated using LCModel (for PRESS and MEGA-PRESS) and ProFit2 (for JPRESS). Statistical Tests The test\textendashretest reliability was evaluated by Wilcoxon signed-rank tests, Pearson\textquotesingles r correlation coefficients, intraclass-correlation coefficients (ICC), coefficients of variation (CV), and by Bland\textendashAltman (BA) plots. The intersequence reliability was assessed with Wilcoxon signed-rank tests, Pearson\textquotesingles r correlation coefficients, and BA plots. Results For GABA, only the MEGA-PRESS sequence showed a moderate test\textendashretest correlation (r \textequals 0.54, ICC \textequals 0.5, CV \textequals 8.8\textpercent) and the BA plots indicated good agreement (P \textgreater 0.05) for all sequences. JPRESS provided less precise results and PRESS was insensitive to GABA. For Glx, the r and ICC values for PRESS (r \textequals 0.87, ICC \textequals 0.9, CV \textequals 2.9\textpercent) and MEGA-PRESS (r \textequals 0.70, ICC \textequals 0.7, CV \textequals 5.3\textpercent) reflect higher correlations, compared with JPRESS (r \textequals 0.39, ICC \textequals 0.4, CV \textequals 20.1\textpercent).}},
  volume = {51},
  number = {4},
  pages = {1181--1191},
  publisher = {Society for Magnetic Resonance Imaging},
  address = {Chicago, IL},
  year = {2020},
  slug = {item_3174176},
  author = {Baeshen, A and Wyss, PO and Henning, A and O\textquotesingleGorman, RL and Piccirelli, M and Kollias, S and Michels, L}
}