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Deep CEST MR Fingerprinting at 7T Reveals Tumor Apoptotic Response to Oncolytic Virotherapy In Vivo
{Oncolytic virotherapy (OV) is a promising treatment for high mortality cancers.1Non-invasive monitoring of OV is essential for optimizing the clinical outcome and providing an improved understanding of the interactions between the virus and its tumor-host. Chemical exchange saturation transfer (CEST) MRI is a molecular imaging technique that may shed new light on OV, as it is capable of detecting pro-tein concentration and pH changes. However, clinical translation of CEST methods has been hindered by the qualitative nature of the image contrast and the long image acquisition times.}
@misc{item_3259329, title = {{Deep CEST MR Fingerprinting at 7T Reveals Tumor Apoptotic Response to Oncolytic Virotherapy In Vivo}}, booktitle = {{11th Annual Scientific Symposium on Ultrahigh Field Magnetic Resonance: Clinical Needs, Research Promises and Technical Solutions}}, abstract = {{Oncolytic virotherapy (OV) is a promising treatment for high mortality cancers.1Non-invasive monitoring of OV is essential for optimizing the clinical outcome and providing an improved understanding of the interactions between the virus and its tumor-host. Chemical exchange saturation transfer (CEST) MRI is a molecular imaging technique that may shed new light on OV, as it is capable of detecting pro-tein concentration and pH changes. However, clinical translation of CEST methods has been hindered by the qualitative nature of the image contrast and the long image acquisition times.}}, pages = {55--57}, year = {2020}, slug = {item_3259329}, author = {Perlman, O and Ito, H and Herz, K and Shono, N and Nakashima, H and Zaiss, M and Chiocca, EA and Cohen, O and Rosen, MS and Farrar, CT} }