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Noradrenergic locus coeruleus ensembles fire at distinct times to evoke different cortical states in rat prefrontal cortex
{The Locus Coeruleus (LC), a noradrenergic brain stem nucleus projecting throughout the forebrain, is thought to act as an undifferentiated state controller across all forebrain targets because LC neurons spike synchronously [1, 2]. However, recent work demonstrated ensembles in the LC and therefore made targeted neuromodulation a possibility [3]. This recent study used graph theory to reveal a static snapshot of LC ensembles. In order to now demonstrate that LC ensembles cause targeted neuromodulation, it is necessary to resolve LC ensemble dynamics over time in relation to ongoing cortical states.}
@misc{item_3274646, title = {{Noradrenergic locus coeruleus ensembles fire at distinct times to evoke different cortical states in rat prefrontal cortex}}, booktitle = {{AREADNE 2020: Research in Encoding and Decoding of Neural Ensembles}}, abstract = {{The Locus Coeruleus (LC), a noradrenergic brain stem nucleus projecting throughout the forebrain, is thought to act as an undifferentiated state controller across all forebrain targets because LC neurons spike synchronously [1, 2]. However, recent work demonstrated ensembles in the LC and therefore made targeted neuromodulation a possibility [3]. This recent study used graph theory to reveal a static snapshot of LC ensembles. In order to now demonstrate that LC ensembles cause targeted neuromodulation, it is necessary to resolve LC ensemble dynamics over time in relation to ongoing cortical states.}}, pages = {94}, publisher = {The AREADNE Foundation}, address = {Cambridge, MA, USA}, year = {2020}, slug = {item_3274646}, author = {Noei, S and Zouridis, I and Logothetis, NK and Panzeri, S and Totah, NK} }