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Improved prospective frequency correction for macromolecule-suppressed GABA editing with metabolite cycling at 3T
{Macromolecule-suppressed GABA-editing with symmetrical suppression is often preferred over conventional GABA-editing due to its greater specificity. However, this pulse sequence is more sensitive to magnetic field instabilities than conventional GABA-editing. This leads to macromolecule contamination in the edited GABA signal. Here, we combine metabolite cycling with J-difference (MC-MEGA) editing to allow for prospective volume-localized frequency correction at each repetition time without the acquisition of additional water reference transients. We show here that prospective MC-MEGA reduces B0 field instability relative to intermittent prospective frequency correction with water suppressed (WS) MEGA and reduces macromolecule contamination and subtraction artifacts.}
@misc{item_3319813, title = {{Improved prospective frequency correction for macromolecule-suppressed GABA editing with metabolite cycling at 3T}}, booktitle = {{2021 ISMRM \& SMRT Annual Meeting \& Exhibition (ISMRM 2021)}}, abstract = {{Macromolecule-suppressed GABA-editing with symmetrical suppression is often preferred over conventional GABA-editing due to its greater specificity. However, this pulse sequence is more sensitive to magnetic field instabilities than conventional GABA-editing. This leads to macromolecule contamination in the edited GABA signal. Here, we combine metabolite cycling with J-difference (MC-MEGA) editing to allow for prospective volume-localized frequency correction at each repetition time without the acquisition of additional water reference transients. We show here that prospective MC-MEGA reduces B0 field instability relative to intermittent prospective frequency correction with water suppressed (WS) MEGA and reduces macromolecule contamination and subtraction artifacts.}}, year = {2021}, slug = {item_3319813}, author = {Chan, K and Hock, A and Edden, R and MacMillan, E and Henning, A} }