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3D 31P MRSI of the human brain at 9.4 Tesla: Optimization and quantitative analysis of metabolic images
{Purpose: To present 31 P whole brain MRSI with a high spatial resolution to probe quantitative tissue analysis of 31 P MRSI at an ultrahigh field strength of 9.4 Tesla. Methods: The study protocol included a 31 P MRSI measurement with an effective resolution of 2.47 mL. For SNR optimization, the nuclear Overhauser enhancement at 9.4 Tesla was investigated. A sensitivity correction was achieved by applying a low rank approximation of the $\gamma$-adenosine triphosphate signal. Group analysis and regression on individual volunteers were performed to investigate quantitative concentration differences between different tissue types. Results: Differences in gray and white matter tissue 31 P concentrations could be investigated for 12 different 31 P resonances. In addition, the first highly resolved quantitative MRSI images measured at B0 \textequals 9.4 Tesla of 31 P detectable metabolites with high SNR could be presented. Conclusion: With an ultrahigh field strength B0 \textequals 9.4 Tesla, 31 P MRSI moves further toward quantitative metabolic imaging, and subtle differences in concentrations between different tissue types can be detected.}
@article{item_3329542, title = {{3D 31P MRSI of the human brain at 9.4 Tesla: Optimization and quantitative analysis of metabolic images}}, journal = {{Magnetic Resonance in Medicine}}, abstract = {{Purpose: To present 31 P whole brain MRSI with a high spatial resolution to probe quantitative tissue analysis of 31 P MRSI at an ultrahigh field strength of 9.4 Tesla. Methods: The study protocol included a 31 P MRSI measurement with an effective resolution of 2.47 mL. For SNR optimization, the nuclear Overhauser enhancement at 9.4 Tesla was investigated. A sensitivity correction was achieved by applying a low rank approximation of the $\gamma$-adenosine triphosphate signal. Group analysis and regression on individual volunteers were performed to investigate quantitative concentration differences between different tissue types. Results: Differences in gray and white matter tissue 31 P concentrations could be investigated for 12 different 31 P resonances. In addition, the first highly resolved quantitative MRSI images measured at B0 \textequals 9.4 Tesla of 31 P detectable metabolites with high SNR could be presented. Conclusion: With an ultrahigh field strength B0 \textequals 9.4 Tesla, 31 P MRSI moves further toward quantitative metabolic imaging, and subtle differences in concentrations between different tissue types can be detected.}}, volume = {Epub ahead}, publisher = {Wiley-Liss}, address = {New York}, year = {2021}, slug = {item_3329542}, author = {Ruhm, L and Dorst, J and Avdievitch, N and Wright, AM and Henning, A} }