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Cortical ß-amyloid plaque load detection using QSM in Alzheimer\textquoterights patients at 9.4T
{Beta-amyloid (A$\beta$) plaques are characteristic of Alzheimer\textquoterights Disease (AD) brain and cause effects which can be detected by QSM. It has been shown that cortical plaque-load could be used to distinguish AD patients from healthy controls (HC) using ultra-high spatial resolution QSM at ultra-high-field (9.4 and 14.1T), in-vivo and ex-vivo. We aimed to extend these observations to a larger cohort of patients and controls at two different spatial resolutions. We found a significative (p\textless0.05) increase in plaque-load in AD compared to HC at both resolutions. Interestingly, some cortical regions also showed greater (p\textless0.05) diamagnetic effects in AD compared to HC.}
@misc{item_3333047, title = {{Cortical \ss-amyloid plaque load detection using QSM in Alzheimer\textquoterights patients at 9.4T}}, booktitle = {{2021 ISMRM \& SMRT Annual Meeting \& Exhibition (ISMRM 2021)}}, abstract = {{Beta-amyloid (A$\beta$) plaques are characteristic of Alzheimer\textquoterights Disease (AD) brain and cause effects which can be detected by QSM. It has been shown that cortical plaque-load could be used to distinguish AD patients from healthy controls (HC) using ultra-high spatial resolution QSM at ultra-high-field (9.4 and 14.1T), in-vivo and ex-vivo. We aimed to extend these observations to a larger cohort of patients and controls at two different spatial resolutions. We found a significative (p\textless0.05) increase in plaque-load in AD compared to HC at both resolutions. Interestingly, some cortical regions also showed greater (p\textless0.05) diamagnetic effects in AD compared to HC.}}, year = {2021}, slug = {item_3333047}, author = {Tuzzi, E and Pohmann, R and Loktyushin, A and Laske, C and Scheffler, K and Hagberg, GE} }