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Histoarchitectonically distinct regions of anterior cingulate show altered glutamatergic metabolism in major depressive disorder
{Increasing evidence suggests a hypoglutamatergic state in major depressive disorder (MDD), however spatial- and metabolite specific abnormalities have not been fully characterized. Using short TE/TM STEAM MRS, we evaluated Glu, Gln, Gln/Glu and GABA metabolism in two histoarchitectonically distinct subdivisions of the anterior cingulate cortex (ACC). The pregenual ACC, involved in emotion processing, showed altered glutamine-glutamine cycling but not altered GABAergic metabolism in MDD, whereas no differences between patients and controls were found in the anteromedial ACC. Increased Gln/Glu in MDD in pgACC but not aMCC confirms a regionally specific role of altered glutamatergic metabolism and neuronal-glial interaction.}
@misc{MartensvCLDDRVLSLW2018, title = {{Histoarchitectonically distinct regions of anterior cingulate show altered glutamatergic metabolism in major depressive disorder}}, booktitle = {{Joint Annual Meeting ISMRM-ESMRMB 2018}}, abstract = {{Increasing evidence suggests a hypoglutamatergic state in major depressive disorder (MDD), however spatial- and metabolite specific abnormalities have not been fully characterized. Using short TE/TM STEAM MRS, we evaluated Glu, Gln, Gln/Glu and GABA metabolism in two histoarchitectonically distinct subdivisions of the anterior cingulate cortex (ACC). The pregenual ACC, involved in emotion processing, showed altered glutamine-glutamine cycling but not altered GABAergic metabolism in MDD, whereas no differences between patients and controls were found in the anteromedial ACC. Increased Gln/Glu in MDD in pgACC but not aMCC confirms a regionally specific role of altered glutamatergic metabolism and neuronal-glial interaction.}}, year = {2018}, slug = {martensvclddrvlslw2018}, author = {Martens, L and von D\"uring, F and Colic, L and Li, S and Demenescu, LR and Denzel, D and Ristow, I and Vogel, M and Lison, S and Speck, O and Li, M and Li, Meng and Walter, M} }