@article{RistowLCMFvSDWWBKPSW2018,
  title = {{Pedophilic sex offenders are characterised by reduced GABA concentration in dorsal anterior cingulate cortex}},
  journal = {{NeuroImage: Clinical}},
  abstract = {{A pedophilic disorder is characterised by abnormal sexual urges towards prepubescent children. Child abusive behavior is frequently a result of lack of behavioral inhibition and current treatment options entail, next to suppressing unchangeable sexual orientation, measures to increase cognitive and attentional control. We tested, if in brain regions subserving attentional control of behavior and perception of salient stimuli, such inhibition deficit can be observed also on the level of inhibitory neurotransmitters. We measured GABA concentration in the dorsal anterior cingulate cortex (dACC) and in a control region, the pregenual anterior cingulate cortex (pgACC) in pedophilic sex offenders (N \textequals 13) and matched controls (N \textequals 13) using a 7 Tesla STEAM magnetic resonance spectroscopy (MRS). In dACC but not in the control region pedophilic sex offenders showed reduced GABA/Cr concentrations compared to healthy controls. The reduction was robust after controlling for potential influence of age and gray matter proportion within the MRS voxel (p \textless 0.04). Importantly, reduced GABA/Cr in patients was correlated with lower self-control measured with the Barratt Impulsiveness Scale (p \textequals 0.028, r \textequals \textminus0.689). In a region related to cognitive control and salience mapping, pedophilic sex offenders showed reduction of the inhibitory neurotransmitter GABA which may be seen as a neuronal correlate of inhibition and behavioral control.}},
  volume = {18},
  pages = {335--341},
  year = {2018},
  slug = {ristowlcmfvsdwwbkpsw2018},
  author = {Ristow, I and Li, M and Colic, L and Marr, V and F\"odisch, C and von D\"uring, F and Schlitz, K and Drumkova, K and Witzel, J and Walter, H and Beier, K and Kruger, THC and Ponseti, J and Schiffer, P and Walter, M}
}