@misc{item_3032330,
  title = {{Relaxation-compensated multi-pool CEST signal at 7T MRI of glioblastomas is dependent on the anatomic localisation}},
  journal = {{Insights into Imaging}},
  abstract = {{Purpose: To investigate the localization dependence of relaxationcompensated multi-pool Chemical-Exchange-Saturation-Transfer (CEST) MRI at 7T and histopathological parameters in newly diagnosed untreated WHO IV\mbox{$^\circ$} glioma patients. Methods and Materials: Twenty patients with newly diagnosed WHO IV\mbox{$^\circ$} gliomas were prospectively included in this study and investigated at a 7T whole-body scanner (Siemens Healthcare, Erlangen, Germany). Mean CEST signal intensities (Nuclear-Overhauser-Effect(NOE), Amide-Proton- Transfer(APT), Downfield\textunderscoreNOE-suppressed APT(DNS\textunderscoreAPT)), ADC parameters and histopathological parameters of the tumor volumes were evaluated with regard to extension, localization (brain hemisphere and lobe) and contact to the subventricular zone using non-parametric Mann-Whitney tests, ANOVA on ranks test and Spearman correlation. Results: Mean CEST APT\&DNS\textunderscoreAPT signal intensities (0,156$\pm$0,118 \& 0,137$\pm$0,116) were significantly increased in right vs. left hemisphere glioblastomas (0,072$\pm$0,014 \& 0,048$\pm$0,014), (p\textequals0,044 and 0,010). Mean ADC parameter were significantly decreased in right vs. left hemisphere glioblastomas (1,04\textasteriskcentered10\textasciicircum7$\pm$0,08\textasteriskcentered10\textasciicircum7 vs. 1,18\textasteriskcentered10\textasciicircum7$\pm$0,12\textasteriskcentered10\textasciicircum7) (p\textequals0,046). Mean CEST NOE signal intensity didn\textquoterightt differ significantly between both hemispheres, but was significantly increased in case of subventricular zone contact (0,101$\pm$0,015 vs. 0,118$\pm$0,015) (p\textequals0,037). The lobe localization and extension of the tumor had no significant effect on CEST and ADC signals. CEST APT\&DNS\textunderscoreAPT and ADC signal intensities did significantly correlate (- 0,67 and -0,56) (p\textless0,01), but not CEST NOE and ADC parameters. Histopathological parameters were not significantly different with regard to different localizations. Conclusion: Relaxation-compensated multi-pool CEST MRI signal depends on the anatomic localization. Amide CEST and ADC are positively correlating - NOE parameters are solemly different with regard to subventricular zone contact, possibly showing complementary information to Amide CEST and ADC.}},
  volume = {9},
  pages = {S381},
  year = {2018},
  slug = {item_3032330},
  author = {Dreher, C and Windschuh, J and Sahm, F and Bachert, P and Ladd, M and Zaiss, M and Schlemmer, H-P and Radbruch, A and Paech, D}
}