Institute Homepage
Institute Homepage DE Sign In

Back

Miscellaneous 2019

Amide proton transfer (APT) MRI is a predictor of survival and progression in high-grade glioma patients

{In this work we show that relaxation-compensated amide proton transfer (APT) imaging at 7.0 T is associated with overall survival and progression-free survival in newly-diagnosed, previously untreated glioma patients. The current study showed that glioma patients with increased APT values were more likely to progress sooner and live shorter, respectively. This effect may be caused by strong alterations of amino acid concentrations and global upregulation of protein expression in more aggressive brain tumors. Therefore, APT CEST imaging may help to enhance the prognostic value of non-invasive MRI tools at the time of initial diagnosis and during follow-up.}

Author(s): Paech, D and Dreher, C and Regnery, S and Meissner, J-E and Goerke, S and Windschuh, J and Deike-Hofmann, K and Bickelhaupt, S and Radbruch, A and Zaiss, M and Unterberg, A and Wick, W and Bendszus, M and Bachert, P and Ladd, M and Schlemmer, H-P
Book Title: ISMRM 27th Annual Meeting & Exhibition
Year: 2019
Bibtex Type: Miscellaneous (misc)
Electronic Archiving: grant_archive

BibTex 

@misc{item_3055303,
  title = {{Amide proton transfer (APT) MRI is a predictor of survival and progression in high-grade glioma patients}},
  booktitle = {{ISMRM 27th Annual Meeting \& Exhibition}},
  abstract = {{In this work we show that relaxation-compensated amide proton transfer (APT) imaging at 7.0 T is associated with overall survival and progression-free survival in newly-diagnosed, previously untreated glioma patients. The current study showed that glioma patients with increased APT values were more likely to progress sooner and live shorter, respectively. This effect may be caused by strong alterations of amino acid concentrations and global upregulation of protein expression in more aggressive brain tumors. Therefore, APT CEST imaging may help to enhance the prognostic value of non-invasive MRI tools at the time of initial diagnosis and during follow-up.}},
  year = {2019},
  slug = {item_3055303},
  author = {Paech, D and Dreher, C and Regnery, S and Meissner, J-E and Goerke, S and Windschuh, J and Deike-Hofmann, K and Bickelhaupt, S and Radbruch, A and Zaiss, M and Unterberg, A and Wick, W and Bendszus, M and Bachert, P and Ladd, M and Schlemmer, H-P}
}