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Novel turn-on luminescent chemosensors selective to zinc ions
{Zinc ions play an important role in many biological processes in human body [1]. To recognize Zn2+ over other metal ions, two novel EuDO3A-based complexes EuL1-2 (DO3A \textendash 1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylic acid) appended with the tyrosine as chromophore and dipicolylamine as recognition moiety were developed as suitable luminescent sensors. Without Zn2+, only weak luminescence of each complex was observed due to the luminescence quenching by the photoinduced electron transfer mechanism. After addition of Zn2+, both probes displayed large increase in the Eucentered luminescent emission; in specific, the emission intensity reached 7-fold and 5-fold enhancement at 617 nm for EuL1 and EuL2, respectively (Figure 1). The ion selectivity experiments demonstrated specificity of our probes toward Zn2+ over other metal ions. Two additional complexes EuL3-4 without a dipicolylamine-moiety were synthesized as references. Both of them did not show obvious luminescent enhancement for any of the studied metal ions, showing the essential role of the dipicolylamines for the recognition of Zn2+. The induced emission changes of the Eu3+ allow precise quantitative analysis of this ion, establishing these lanthanide-based complexes as useful chemosensors for potential biological applications.}
@misc{item_3152803, title = {{Novel turn-on luminescent chemosensors selective to zinc ions}}, booktitle = {{Progressive Trends in Coordination, Bioinorganic, and Applied Inorganic Chemistry}}, abstract = {{Zinc ions play an important role in many biological processes in human body [1]. To recognize Zn2+ over other metal ions, two novel EuDO3A-based complexes EuL1-2 (DO3A \textendash 1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylic acid) appended with the tyrosine as chromophore and dipicolylamine as recognition moiety were developed as suitable luminescent sensors. Without Zn2+, only weak luminescence of each complex was observed due to the luminescence quenching by the photoinduced electron transfer mechanism. After addition of Zn2+, both probes displayed large increase in the Eucentered luminescent emission; in specific, the emission intensity reached 7-fold and 5-fold enhancement at 617 nm for EuL1 and EuL2, respectively (Figure 1). The ion selectivity experiments demonstrated specificity of our probes toward Zn2+ over other metal ions. Two additional complexes EuL3-4 without a dipicolylamine-moiety were synthesized as references. Both of them did not show obvious luminescent enhancement for any of the studied metal ions, showing the essential role of the dipicolylamines for the recognition of Zn2+. The induced emission changes of the Eu3+ allow precise quantitative analysis of this ion, establishing these lanthanide-based complexes as useful chemosensors for potential biological applications.}}, pages = {120}, publisher = {Slovak Chemical Society}, address = {Bratislava, Slovakia}, year = {2019}, note = {author: Tatarko, M}, slug = {item_3152803}, author = {Wang, G and Angelovski, G} }