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A low-molecular-weight ditopic MRI probe for ratiometric sensing of zwitterionic amino acid neurotransmitters
{We report a novel ditopic Gd(III)-based probe selective to zwitterionic amino acid neurotransmitters (ZNTs) crafted for ratiometric MRI imaging. The probe displayed increased binding affinity to ZNTs and non-synchronized concentration-dependent changes of the r1- and r2-relaxivity. Through the application of a T2/T1 weighted MRI strategy, we demonstrated signal enhancement for cooperatively bound glutamate and $\gamma$-aminobutyric acid ZNTs over competitive hydrogencarbonate, which remained MR silent.}
@article{item_3165185, title = {{A low-molecular-weight ditopic MRI probe for ratiometric sensing of zwitterionic amino acid neurotransmitters}}, journal = {{Chemical Communications}}, abstract = {{We report a novel ditopic Gd(III)-based probe selective to zwitterionic amino acid neurotransmitters (ZNTs) crafted for ratiometric MRI imaging. The probe displayed increased binding affinity to ZNTs and non-synchronized concentration-dependent changes of the r1- and r2-relaxivity. Through the application of a T2/T1 weighted MRI strategy, we demonstrated signal enhancement for cooperatively bound glutamate and $\gamma$-aminobutyric acid ZNTs over competitive hydrogencarbonate, which remained MR silent.}}, volume = {55}, number = {79}, pages = {11924--11927}, publisher = {Royal Society of Chemistry}, address = {Cambridge, UK}, year = {2019}, slug = {item_3165185}, author = {Tolji\'c, \DJ and Angelovski, G} }