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An Open Resource for Non-human Primate Optogenetics
{Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and unsuccessful, of using optogenetics in the primate brain. We contacted members of the community to ask for their contributions to an open science initiative. As of this writing, 45 laboratories around the world contributed more than 1,000 injection experiments, including precise details regarding their methods and outcomes. Of those entries, more than half had not been published. The resource is free for everyone to consult and contribute to on the Open Science Framework website. Here we review some of the insights from this initial release of the database and discuss methodological considerations to improve the success of optogenetic experiments in NHPs.}
@article{item_3259832, title = {{An Open Resource for Non-human Primate Optogenetics}}, journal = {{Neuron}}, abstract = {{Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and unsuccessful, of using optogenetics in the primate brain. We contacted members of the community to ask for their contributions to an open science initiative. As of this writing, 45 laboratories around the world contributed more than 1,000 injection experiments, including precise details regarding their methods and outcomes. Of those entries, more than half had not been published. The resource is free for everyone to consult and contribute to on the Open Science Framework website. Here we review some of the insights from this initial release of the database and discuss methodological considerations to improve the success of optogenetic experiments in NHPs.}}, volume = {108}, number = {6}, pages = {1075--1090}, publisher = {Cell Press}, address = {Cambridge, Mass.}, year = {2020}, slug = {item_3259832}, author = {Tremblay, S and Acker, L and Afraz, A and Albaugh, DL and Amita, H and Andrei, AR and Angelucci, A and Aschner, A and Balan, PF and Basso, MA and Benvenuti, G and Bohlen, MO and Caiola, MJ and Calcedo, R and Cavanaugh, J and Chen, Y and Chernov, MM and Clark, AM and Dai, J and Debes, SR and Deisseroth, K and Desimone, R and Dragoi, V and Egger, SW and Eldridge, MAG and El-Nahal, HG and Fabbrini, F and Federer, F and Fetsch, CR and Fortuna, MG and Friedman, RM and Fujii, N and Gail, A and Galvan, A and Ghosh, S and Gieselmann, MA and Gulli, RA and Hikosaka, O and Hosseini, EA and Hu, X and H\"uer, J and Inoue, K-I and Janz, R and Jazayeri, M and Jiang, R and Ju, N and Kar, K and Klein, C and Kohn, A and Komatsu, M and Maeda, K and Martinez-Trujillo, JC and Matsumoto, M and Maunsell, JHR and Mendoza-Halliday, D and Monosov, IE and Muers, RS and Nurminen, L and Ortiz-Rios, M and O\textquotesingleShea, DJ and Palfi, S and Petkov, CI and Pojoga, S and Rajalingham, R and Ramakrishnan, C and Remington, EC and Revsine, D and Roe, AW and Sabes, PN and Saunders, RC and Scherberger, H and Schmid, MC and Schultz, W and Seidemann, E and Senova, Y-S and Shadlen, MN and Sheinberg, DL and Siu, C and Smith, Y and Solomon, SS and Sommer, MA and Spudich, JL and Stauffer, WR and Takada, M and Tang, S and Thiele, A and Treue, S and Vanduffel, W and Vogels, R and Whitmire, MP and Wichmann, T and Wurtz, RH and Xu, H and Yazdan-Shahmorad, A and Shenoy, KV and DiCarlo, JJ and Platt, ML} }