@article{item_3244213,
  title = {{The value of what'ts to come: Neural mechanisms coupling prediction error and the utility of anticipation}},
  journal = {{Science Advances}},
  abstract = {{Having something to look forward to is a keystone of well-being. Anticipation of a future reward, like an upcoming vacation, can often be more gratifying than the very experience itself. Theories of anticipation have described how it induces behaviors ranging from beneficial information-seeking through to harmful addiction. However, it remains unclear how neural systems compute an attractive value from anticipation, instead of from the reward itself. To address this gap, we administered a decision-making task to human participants that allowed us to analyze brain activity during receipt of information predictive of future pleasant outcomes. Using a computational model of anticipatory value that captures participants\textquoteright decisions, we show that an anticipatory value signal is orchestrated by influences from three brain regions. Ventromedial prefrontal cortex (vmPFC) tracks the value of anticipation; dopaminergic midbrain responds to information that enhances anticipation, while sustained hippocampal activity provides a functional coupling between these regions. This coordinating function of the hippocampus is consistent with its known role in episodic future thinking. Our findings shed new light on the neural underpinnings of anticipation\textquoterights influence over decision-making, while also unifying a range of phenomena associated with risk and time-delay preference.}},
  volume = {6},
  pages = {1--16},
  publisher = {AAAS},
  address = {Washington},
  year = {2020},
  slug = {item_3244213},
  author = {Iigaya, K and Hauser, TU and Kurth-Nelson, Z and O'Doherty, JP and Dayan, P and Dolan, RJ}
}