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Sensitivity and resolution improvement for in-vivo magnetic resonance current density imaging (MRCDI) of the human brain
{Effective use of transcranial electrical stimulation (TES) in clinical and neuroscience applications requires the exact knowledge of TES currents. MRCDI uses MRI to measure the TES-induced magnetic fields for estimating the underlying current flow distributions. Their accuracy highly depends on the sensitivity and spatial resolution of the MR measurements. Here, we propose an advanced gradient-echo-based MRCDI method utilizing an optimized spoiling, acquisition-weighting, and navigators to achieve a noise sensitivity of 84pT at 2$\times$2$\times$3mm3 resolution for a total scan time of less than five minutes. We test the method\textquotesingles performance by phantom and human in-vivo experiments for two TES injection profiles.}
@misc{item_3319881, title = {{Sensitivity and resolution improvement for in-vivo magnetic resonance current density imaging (MRCDI) of the human brain}}, journal = {{2021 ISMRM \& SMRT Annual Meeting \& Exhibition (ISMRM 2021)}}, abstract = {{Effective use of transcranial electrical stimulation (TES) in clinical and neuroscience applications requires the exact knowledge of TES currents. MRCDI uses MRI to measure the TES-induced magnetic fields for estimating the underlying current flow distributions. Their accuracy highly depends on the sensitivity and spatial resolution of the MR measurements. Here, we propose an advanced gradient-echo-based MRCDI method utilizing an optimized spoiling, acquisition-weighting, and navigators to achieve a noise sensitivity of 84pT at 2$\times$2$\times$3mm3 resolution for a total scan time of less than five minutes. We test the method\textquotesingles performance by phantom and human in-vivo experiments for two TES injection profiles.}}, year = {2021}, slug = {item_3319881}, author = {Goeksu, C and Scheffler, K and Gregersen, F and Ero\u{g}lu, HH and Heule, R and Siebner, HR and Hanson, LG and Thielscher, A} }