@article{item_3231476,
  title = {{Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level}},
  journal = {{Cell}},
  abstract = {{Goal-directed behavior requires the interaction of multiple brain regions. How these regions and their interactions with brain-wide activity drive action selection is less understood. We have investigated this question by combining whole-brain volumetric calcium imaging using light-field microscopy and an operant-conditioning task in larval zebrafish. We find global, recurring dynamics of brain states to exhibit pre-motor bifurcations toward mutually exclusive decision outcomes. These dynamics arise from a distributed network displaying trial-by-trial functional connectivity changes, especially between cerebellum and habenula, which correlate with decision outcome. Within this network the cerebellum shows particularly strong and predictive pre-motor activity (\textgreater10 s before movement initiation), mainly within the granule cells. Turn directions are determined by the difference neuroactivity between the ipsilateral and contralateral hemispheres, while the rate of bi-hemispheric population ramping quantitatively predicts decision time on the trial-by-trial level. Our results highlight a cognitive role of the cerebellum and its importance in motor planning.}},
  volume = {180},
  number = {3},
  pages = {536--551},
  publisher = {Cell Press},
  address = {Cambridge, Mass.},
  year = {2020},
  slug = {item_3231476},
  author = {Lin, Q and Manley, J and Helmreich, M and Schlumm, F and Li, JM and Robson, DN and Engert, F and Schier, A and N\"obauer, T and Vaziri, A}
}