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Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables in vivo MRI probe quantification
{We developed a nanosized perfluorocarbon-based system with incorporated paramagnetic Gd(iii) chelates, able to generate a quantitative 19F MRI signal, while in parallel capable of modulating the 1H MRI signal in response to the coordination of Ca2+ ions. Subsequently, we performed experiments in vivo and estimated the concentration of the applied probe in the tissue by means of 19F MRI.}
@article{item_3247184, title = {{Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables in vivo MRI probe quantification}}, journal = {{Chemical Communications}}, abstract = {{We developed a nanosized perfluorocarbon-based system with incorporated paramagnetic Gd(iii) chelates, able to generate a quantitative 19F MRI signal, while in parallel capable of modulating the 1H MRI signal in response to the coordination of Ca2+ ions. Subsequently, we performed experiments in vivo and estimated the concentration of the applied probe in the tissue by means of 19F MRI.}}, volume = {56}, number = {66}, pages = {9433--9436}, publisher = {Royal Society of Chemistry}, address = {Cambridge, UK}, year = {2020}, slug = {item_3247184}, author = {Gambino, G and Gambino, T and Angelovski, G} }