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Multiple Interleaved Mode Saturation (MIMOSA) for B1+ inhomogeneity mitigation in chemical exchange saturation transfer
{Due to high sensitivity to B1+-inhomogeneities, Chemical Exchange Saturation Transfer MRI requires a correction or mitigation of the B1+-inhomogeneity at ultra-high magnetic field strengths (B0 $\geq$ 7 Tesla). A novel approach for mitigation of B1+-inhomogeneity effects that affects the saturation process is presented. The method employs two interleaved excitation modes during the saturation pulse train. Simulations show a decrease of the relative difference of the MTRRex metric caused by B1+ inhomogeneity. This \textquotedblleftMultiple Interleaved Mode Saturation\textquotedblright scheme leads to improved homogeneity in both, phantom and in vivo measurements at 7 Tesla.}
@misc{LiebertZGSLLUN2018, title = {{Multiple Interleaved Mode Saturation (MIMOSA) for B1+ inhomogeneity mitigation in chemical exchange saturation transfer}}, booktitle = {{Joint Annual Meeting ISMRM-ESMRMB 2018}}, abstract = {{Due to high sensitivity to B1+-inhomogeneities, Chemical Exchange Saturation Transfer MRI requires a correction or mitigation of the B1+-inhomogeneity at ultra-high magnetic field strengths (B0 $\geq$ 7 Tesla). A novel approach for mitigation of B1+-inhomogeneity effects that affects the saturation process is presented. The method employs two interleaved excitation modes during the saturation pulse train. Simulations show a decrease of the relative difference of the MTRRex metric caused by B1+ inhomogeneity. This \textquotedblleftMultiple Interleaved Mode Saturation\textquotedblright scheme leads to improved homogeneity in both, phantom and in vivo measurements at 7 Tesla.}}, year = {2018}, slug = {liebertzgsllun2018}, author = {Liebert, A and Zaiss, M and Gumbrecht, R and Schmitt, B and Linz, P and Laun, FB and Uder, M and Nagel, AM} }