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Simulation of 13C labeling Effects of Glutamate and Glutamine in 1H MR Spectra with different Pulse Sequences at 9.4 T
{Glutamate related metabolism can be measured considering the 13C labeling effects from an administered 13C labeled substrate in pure 1H MRS spectra without a 13C channel. In this work, simulated 1H MRS spectra with FID, semi-Laser, and two PRESS sequences have been compared to optimize spectral resolution for glutamate and glutamine measurements at 9.4 T. Furthermore, spectral changes according to a two-compartment model were analyzed. As a result, this work indicates the fastest possible acquisition can be obtained with an FID sequence, while the best resolution possible can be obtained with a PRESS sequence.}
@misc{ZiegsH2018, title = {{Simulation of 13C labeling Effects of Glutamate and Glutamine in 1H MR Spectra with different Pulse Sequences at 9.4 T}}, booktitle = {{Joint Annual Meeting ISMRM-ESMRMB 2018}}, abstract = {{Glutamate related metabolism can be measured considering the 13C labeling effects from an administered 13C labeled substrate in pure 1H MRS spectra without a 13C channel. In this work, simulated 1H MRS spectra with FID, semi-Laser, and two PRESS sequences have been compared to optimize spectral resolution for glutamate and glutamine measurements at 9.4 T. Furthermore, spectral changes according to a two-compartment model were analyzed. As a result, this work indicates the fastest possible acquisition can be obtained with an FID sequence, while the best resolution possible can be obtained with a PRESS sequence.}}, year = {2018}, slug = {ziegsh2018}, author = {Ziegs, T and Henning, A} }